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An. bras. dermatol ; 85(4): 571-572, jul.-ago. 2010. ilus
Article in Portuguese | LILACS | ID: lil-560595

ABSTRACT

Duas adolescentes e uma menina com vitiligo clinicamente diagnosticado foram tratadas com 8-metoxipsoraleno a 0,2 por cento em creme Lanette com subsequente exposição solar. Um ano após, apresentaram máculas acrômicas na área do vitiligo. A biópsia de pele em um dos casos revelou melanócitos com escassa pigmentação melânica. Os achados clínicos e histológicos sugerem o diagnóstico de leucodermia punctata.


Two adolescent females and a girl, all with clinically diagnosed vitiligo, were treated with 0.2 percent 8-methoxypsoralen cream followed by exposure to solar ultraviolet light. One year later, they developed hypopigmented and achromic spots on the areas affected by the vitiligo. Biopsy of skin tissue taken from one of these cases showed a marked reduction in melanin. Clinical and histological findings point to a diagnosis of leukoderma punctata.


Subject(s)
Adolescent , Child , Female , Humans , Methoxsalen/adverse effects , PUVA Therapy/adverse effects , Photosensitizing Agents/adverse effects , Pigmentation Disorders/etiology , Methoxsalen/therapeutic use , Photosensitizing Agents/therapeutic use , Pigmentation Disorders/pathology , Vitiligo/drug therapy
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